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If you know answers on any questions on this forum, please feel free to answer them. (PS: I try to answer at least once a week or when possible, - Robert)
Pure guessing here, but maybe splitting the reference ground plane?
You should try to avoid routing or having voids on reference planes, because that might affect the signal integrity of hight speed signals running above them. This happens in the case when return currents cannot travel directly under the high speed signal because of void in the reference plane.
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